This moment version of the pioneering paintings in this sizzling subject captures the foremost tendencies and most modern achievements within the paintings of uneven catalysis on an business scale. a couple of thoroughly new real-life case stories written via the area leaders of their respective components offer a compact and certified perception into this constructing box. The ensuing prepared reference and guide collates first-hand and helpful info inside of a context the place it may be simply found.
The high quality contributions illustrate the correct environments and occasions, reminiscent of time strain, how the catalytic step suits into the final synthesis, or festival with different man made methods, in addition to the common difficulties encountered within the numerous stages, together with finding/developing the catalyst and optimization of the method or collection of gear. either profitable and unsuccessful ways to resolve those difficulties are defined.
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Additional info for Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions, Second Edition
1992) The convergent synthesis of (4R-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4 -acetate, a key intermediate for the preparation of CI-981, a highly potent, tissue selective inhibitor of HMG-CoA reductase. , 33, 2279–2282. A. (2000) The catalytic asymmetric aldol reaction. Angew. Chem. Int. , 39, 1352–1374. , and Mink, D. (2006) Directed evolution of an industrial biocatalyst: 2-deoxy- D-ribose 5-phosphate aldolase. Biotechnol. , 1, 537–548. , 14. 15. 16. 17. 18. 19. 20. 21.
The best system contained (S)-3,5-iPr-MeOBIPHEP as diphosphine and (R,R)-DPEN as diamine. However, the highest S/C ratio achieved was only 2000 at 40 bar and 40 ◦ C. Moreover, these hydridotetrahydroborato catalysts showed partial decomposition within weeks even when stored in a refrigerator under argon or in a glove-box (<1 ppm O2 ). Therefore, the work on the robust and stable ruthenium dichloro catalysts was resumed and particular attention was devoted to the type of base used. , acetate, formate, hydrogencarbonate) were able to activate efﬁciently the ruthenium dichloro catalysts and promoted the formation of only traces, if any, of self-condensation products of 13 .
Acad. Sci. USA, 101, 5788–5793. , and Xie, J. (2006) Process for producing atorvastatin, pharmaceutically acceptable salts thereof and intermediates thereof. Patent WO 2006134482. , and Avdagic, A. (2007) An efﬁcient synthesis of (S)-3-aminomethyl-5-methylhexanoic acid (pregabalin) via quinine-mediated desymmetrization of cyclic anhydride. Tetrahedron: Asymmetry, 18, 1481–1485. K. (1997) Chemical development of CI-1008, an enantiomerically pure anticonvulsant. Org. Process Res. , 1, 26–38. A. et al.