By J. Skoda, Peter Langen
Read or Download Antimetabolites in Biochemistry, Biology and Medicine. Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10–12, 1978 PDF
Similar biology books
This quantity is a reprint of a vintage publication approximately Nautilus, first released in 1987, with an introductory bankruptcy summarizing all the paintings on Nautilus and its habitat because the book of the 1st variation greater than two decades in the past. The surge in articles within the final twenty years exhibits an improved curiosity within the topic, reflecting a renewed appreciation of the complexity and fragility of the marine habitat and its biota.
The idea of stochastic approaches offers a big arsenal of equipment appropriate for reading the impression of noise on a variety of platforms. Noise-induced, noise-supported or noise-enhanced results occasionally provide an evidence for as but open difficulties (information transmission within the anxious procedure and data processing within the mind, procedures on the telephone point, enzymatic reactions, and so on.
After quantity 33, this publication sequence was once changed through the magazine "Evolutionary Biology. " Please stopover at www. springer. com/11692 for additional info. the present quantity contains articles at the conceptual courting of ontogeny, phylogeny, and category; correlation stories of spatial styles of genetic edition; and the evolution of flower reveal and gift.
Between unconventional brokers and unclassified viruses the contributions to this quantity excited about prion-related ailments, with particular emphasis on bovine spongiform encephalopathy and human spongiform encephalopathies, and Borna ailment virus, an agent recognized given that very long time to be pathogenic for horses and sheep, that is now mentioned as a possible pathogen for people.
- Evolutionary Biology
- Nitric Oxide Protocols (Methods in Molecular Biology Vol 100)
- In Situ Hybridization Protocols 2nd Edition (Methods in Molecular Biology Vol 123)
- Plant Responses to Drought Stress: From Morphological to Molecular Features
- Ammonites néocrétacées du Menabe (Madagascar). IV. Les Phylloceratidae. V. Les Gaudryceratidae. VI. Les Tetragonitidae
- Toll-Like Receptors: Methods and Protocols
Additional resources for Antimetabolites in Biochemistry, Biology and Medicine. Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10–12, 1978
Capizzi, Κ. K. Stinson, and A. C. Sartorelli, Studies of the antineoplastic activity and metabolism of α-(N)-heterocyclic carboxaldehyde thiosemicarbazones in dogs and mice, Cancer Res. 32, 565 (1972). (7) R. C. DeConti, B. R. Toftness, K. C. Agrawal, R. Tomchick, J. A. R. Mead, J. R. Bertino, A. C. Sartorelli, and W. A. Creasey, Clinical and pharmacological studies with 5-hydroxy2-formylpyridine thiosemicarbazone, Cancer Res. 32, 455 (1972). (8) I. H. Krakoff, E. Etubanas, C. Tan, K. Mayer, V.
Agents of this class also cause inhibition of the formation of RNA and protein; however, these biochemical pathways are much less susceptible to these heteroaromatic thiosemicarbazones (10-14). Interference with the biosyntheses of DNA by these agents has been demonstrated to be due to inhibition of the enzyme ribonucleoside diphosphate reductase (10-12,14,15). 56 Development of α-(Ν)-Heterocyclic Carboxaldehyde Thiosemicarbazones The α-(N)-heterocyclic carboxaldehyde thiosemicarbazones constitute as a class the most potent known inhibitors of ribonucleoside diphosphate reductase; the comparative 50% inhibitory concentrations of IQ-1 and 5-HP with two other known inhibitors of this enzyme, hydroxyurea and guanazole, are shown in Table 1.
323-350. (20) J . H. Galivan, G. F. Maley and F. Maley, Biochemistry 15, 356 (1976). (21) C. Heidelberger, D. G. Parsons and D. C. Remy, J . Med. Chem. 7, 1 (1964). (22) Τ. T. Sakai and D. V. Santi, J . Med. Chem. 16, 1079 (1973). (23) D. V. Santi and Τ. T. Sakai, Biochemistry 10, 3598 (1971). (24) I. H. Pitman, M. J . Cho and G. S. Rork, J . Am. Chem. Soc. 96, 1840 (1974). " (25) R. B. Dunlap, N. G. L. Harding and F. M. Huennekens, Biochemistry 10, 88 (1971). 53 Irreversible THE DEVELOPMENT OF α-(N)-HETEROCYCLIC CARBOXALDEHYDE THIOSEMICARBAZONES AS INHIBITORS OF RIBONUCLEOTIDE REDUCTASE Alan C.