By Esen Özkaya, Kurtuluş Didem Yazganoğlu
Adverse cutaneous drug reactions (ACDR) are one of the such a lot common occasions in sufferers receiving drug treatment. Cardiovascular (CV) medicines are a major staff of substances with power danger of constructing ACDR specifically in aged as advertising and marketing of extra new medications and their prescription proceed to extend. besides the fact that, like with such a lot different medications the precise occurrence of cutaneous unintended effects from CV medicinal drugs is hard to estimate because of sporadic reporting. furthermore, a competent designation of a undeniable drug because the explanation for a undeniable kind of response can hardly be made. except the well known angioedema/urticaria from ACE inhibitors, lichen planus / lichenoid response from beta adrenergic blockers and photosensitivity from thiazid diuretics, ACDR from CV medicinal drugs will be obvious in a large spectrum extending to infrequent yet life-threatening stipulations resembling erythroderma, Stevens-Johnson syndrome, poisonous epidermal necrolysis or drug allergy syndrome. during this entire overview, the mentioned varieties of ACDR to CV medicinal drugs might be mentioned in line with drug category and the kind of dermatologic response with distinctive emphasize on cross-reactions and the position of patch checking out in diagnosis.
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Additional info for Adverse Cutaneous Drug Reactions to Cardiovascular Drugs
Cardiovascular drugs such as anticoagulants, methyldopa, statins, CCBs, and thiazides were also found to be associated with eczematous drug eruptions . Heparin and telmisartan–hydrochlorothiazide have been reported to induce BS/SDRIFE [14, 15]. Lichenoid Drug Eruption Lichenoid drug eruption resembles idiopathic lichen planus that is characterized by pruritic, small, shiny, reddish to violaceous polygonal papules with white scaly appearance on the surface caused by Wickham’s striae (Figs. 20).
The face, neck, trunk, and extremities including the palms and soles are usually involved. Histopathology of bullous lesions shows full-thickness epidermal necrosis with subepidermal blistering. At least one mucosal area is involved such as oral, genital, conjunctival, pharyngeal, laryngeal, or perianal, showing painful hemorrhagic bullae and erosions. The lips are typically covered with hemorrhagic crusts (Fig. 59). Oral candidiasis may develop as a consequence of disturbed oral hygiene. Bronchitis, pneumonia, pericarditis, glomerulonephritis, and hepatitis may develop.
17 Symmetrical lesions on major flexural and intertriginous areas such as the axillae and antecubital fossae in SDRIFE (symmetrical drug-related intertriginous and flexural exanthema) other intertriginous/flexural fold, (4) symmetry of affected areas, and (5) absence of systemic symptoms and signs . Beta-lactam antibiotics such as amoxicillin and ampicillin are the main inducers of eczematous drug eruption. Cardiovascular drugs such as anticoagulants, methyldopa, statins, CCBs, and thiazides were also found to be associated with eczematous drug eruptions .